1. What was the specific original intent of the intervention or procedure described in each of the papers and what was their unintended consequence(s)?

2. Can you offer a solution or remediation for any or all of the resulting consequences from these interventions?

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What was the specific original intent of the intervention or procedure described in each of the papers and what was their unintended consequence(s)?
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3 .What is the Hygiene Hypothesis (described in the Roduit paper) and how is it related to this discussion?

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