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Based on the following introduction, identify the problem statement, significance to nursing, and hypotheses/research questions.
Breast cancer is the second most common cancer in the world
as well as in Korean women [1, 2]. With an increase of active
breast cancer screening and improvement in treatment, early
detection and treatment of breast cancer have contributed
to reduced breast cancer mortality, but breast cancer is still
the leading cause of cancer-related death [3]. Treatments for
breast cancer depend on the type and stage of breast cancer
and conventional treatment includes combination of surgery,
radiotherapy, chemotherapy, endocrine therapy, and targeted
therapy. For decades, many effective drugs for breast cancer
have been developed and for chemotherapy, tannest such as
paclitaxel and dovetail have remained standard therapeutic
agent in breast cancer [4]. As with most chemotherapeutic
drugs, tannest attack cancer cells but also affect healthy cells
and can cause a number of side effects. One of the side effects
of taxman is peripheral nephropathy.
a homeopathic disorder caused by neurotoxin and/or early discontinuation of chemotherapy [6, 7]. Also,
CIPRO can severely impair quality of life (Qom). However,
although several promising methods including some natural
products and complementary therapies have been suggested
[8], there are no definite treatments for CIPRO yet [7, 9].
Previous studies have suggested that acupuncture is
effective in reducing peripheral nephropathy caused by other
primary disease [10] and CIPRO among patients with various
cancer types [11–13]. Schroeder et al. [13] showed a positive
effect of acupuncture on CIPRO in patients who underwent
chemotherapy with different regimens for the treatment of
colon cancer, bronchial cancer, lymphoma, and breast cancer.
However, there are limited reports focusing on breast cancer
among studies on the effects of acupuncture for treatment of
CIPRO and there are no available data in Korean breast cancer
In recent years, acupuncture is increasingly being inter-
grated into adjutant treatment of cancer patients [14], but the
protocol of acupuncture is not standardized and the treat-
men outcomes are inconsistent [15]. To utilize acupuncture
for the treatment of CIPRO in breast cancer based on evidence-
based medicine, more data on clinical trials are necessary. In
this study, we aimed to investigate the effects and safety of
acupuncture for treatment of CIPRO in Korean breast cancer
patients. We also evaluated Qom of the patients suffering from
CIPRO. As far as we know, this is the first prospective study to
show the data on the effects of acupuncture on the treatment
cancer patients with CIPRO in Korea. chemotherapy-
peptic agents including tannest [5]. CIPRO is a dose-limiting
side effect and severe symptoms can lead to a dose reduction.

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