Your submitted work should include the following:
• A brief description of the design of the experiment and how the data was collected.
• Your data recorded in tables with concentration used of both agonists and the corresponding antagonists.
You discussion should include consideration of the following:
1. The nature of acetylcholine and histamine and how they produce contraction of the smooth muscle (dynamics: receptors, type and drug-receptor interaction)
2. Identify two drugs that can act on muscarinic and histaminergic receptors in the gastric system (one drug for each type of receptor) and describe their mechanism of action and their therapeutic applications.
Using Excel:
• Convert the contraction values into % response and the dose into log10 for each drug
• Plot the following graphs:
the %response vs. log10 dose for acetylcholine (with and without the antagonist, 2 curves in the same plot)
the %response vs. log10 dose for histamine (with and without the antagonist, 2 curves in the same plot)
Describe the two plots:
Compare the 2 dose-response curves for acetylcholine and histamine (without antagonists): which agonist is the most potent?
Analyse the effect of the antagonists on the dose-response curves for both acetylcholine and histamine. How would you describe the mechanism of action of both atropine and mepyramine on their respective receptors?

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Identify two drugs that can act on muscarinic and histaminergic receptors in the gastric system one drug for each type of receptor and describe their mechanism of action and their therapeutic
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